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Jyh-Ming Lien, Marco Morales, Nancy M. Amato, "Neuron PRM: A Framework for Constructing Cortical Networks," Technical Report, TR01-002, Parasol Laboratory, Department of Computer Science, Texas A&M University, Oct 2001.
Technical Report(ps, pdf, abstract)

The brain has extraordinary computational power to represent and interpret complex natural environments. These natural computations are essentially determined by the topology and geometry of the brain's architectures. We present a framework to construct a 3D model of a cortical network using probabilistic roadmap methods. Although not the usual motion planning problem, our objective of building a network that encodes the pathways of the cortical network is analogous to the PRM objective of constructing roadmaps that contain a representative sample of feasible paths. We represent the network as a large-scale directed graph, and use L-systems and statistics data to `grow' neurons that are morphologically indistinguishable from real neurons. We detect connections (synapses) between neurons using geometric proximity tests.